Clofexamide

Clofexamide
Clinical data
Routes of; administration	Oral, rectal, topical
ATC code	None;
Legal status
Legal status	Discontinued;
Identifiers
	IUPAC name 2-(4-Chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide;
CAS Number	1223-36-5;
PubChem CID	28554;
ChemSpider	26562;
ChEMBL	ChEMBL2106515;
CompTox Dashboard (EPA)	DTXSID6046424 ;
ECHA InfoCard	100.013.592
Chemical and physical data
Formula	C14H21ClN2O2
Molar mass	284.782 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCNC(=O)COC1=CC=C(C=C1)Cl;
	InChI InChI=1S/C14H21ClN2O2/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h5-8H,3-4,9-11H2,1-2H3,(H,16,18); Key:UORGKWWJEQDTGX-UHFFFAOYSA-N;

Clofexamide (or amichlophene) is an antidepressant that was a component of the drug combination clofezone, the other being the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone. Clofezone was used to treat joint and muscular pain, but is not marketed any more.[1][2]

References

Berger, Artur; Wachter, Helmut, eds. (1998). Hunnius Pharmazeutisches Wörterbuch (in German) (8 ed.). Walter de Gruyter Verlag. p. 343. ISBN 3-11-015793-4.
Reinicke, C.; Helbing, M.; Klingenfeld, U.; Lasaroff, I.; Wessel, G. (1984). "Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)". Die Pharmazie. 39 (12): 824–827. PMID 6241720.

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