Estradiol/levonorgestrel

Estradiol/levonorgestrel (E2/LNG), sold under brand name Climara Pro, is a combination of estradiol (E2) and levonorgestrel (LNG) which is used in menopausal hormone therapy.[1][2][3] It is a 22-cm2 transdermal patch containing 4.4 mg estradiol and 1.39 mg levonorgestrel and delivers 45 μg/day estradiol and 15 μg/day levonorgestrel.[1][4] E2/LNG was approved for medical use in the United States in 2003.[5]

Estradiol/levonorgestrel
Combination of
EstradiolEstrogen
LevonorgestrelProgestogen
Clinical data
Trade namesClimara Pro
Other namesE2/LNG
ATC code
Legal status
Legal status

See also

References
  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021885lbl.pdf
  2. Shulman, Lee P (2005). "17β-Estradiol/levonorgestrel transdermal system for the management of the symptomatic menopausal woman". Expert Opinion on Pharmacotherapy. 5 (12): 2559–2566. doi:10.1517/14656566.5.12.2559. ISSN 1465-6566. PMID 15571472.
  3. Dando, Toni M; Perry, Caroline M (2004). "17??-Estradiol/Levonorgestrel Transdermal System". Treatments in Endocrinology. 3 (5): 319–324. doi:10.2165/00024677-200403050-00005. ISSN 1175-6349. PMID 15330679.
  4. Wiedersberg, Sandra; Guy, Richard H. (2014). "Transdermal drug delivery: 30+ years of war and still fighting!" (PDF). Journal of Controlled Release. 190: 150–156. doi:10.1016/j.jconrel.2014.05.022. ISSN 0168-3659. PMID 24852092.
  5. Traynor, Kate (2004). "New drug and biological product approvals, 2003". American Journal of Health-System Pharmacy. 61 (4): 338–340. doi:10.1093/ajhp/61.4.338. ISSN 1079-2082. PMID 15011760.



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