Chronotherapy (treatment scheduling)

Chronotherapy, also called chronotherapeutics[1] or chronotherapeutic drug delivery,[2] refers to the use of circadian or other rhythmic cycles of a condition's symptoms and/or of the individual being treated in the application of therapy.[2] Examples of this are treatments of psychiatric and somatic diseases that are administered according to a schedule that corresponds to these rhythms in order to maximize effectiveness and minimize side effects of the therapy.[3]

"Chronotherapy" redirects here. For other uses, see Chronotherapy (sleep phase).

Chronotherapy (treatment scheduling)
MeSHD019454

Chronotherapy is used in various clinical fields such as the treatments of asthma,[4][5] hypertension,[6] and bipolar disorder[7][8].

In the treatment of psychiatric conditions including bipolar depression[9][10], a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.[11][12][13]

See also

References
  1. "Medical dictionary". Merriam-Webster. Retrieved 6 January 2017.
  2. Sajan J (October 2009). "Chronotherapeutics and Chronotherapeutic Drug Delivery Systems". Tropical Journal of Pharmaceutical Research. 8 (5): 467–475. doi:10.4314/tjpr.v8i5.48091. ISSN 1596-5996. Retrieved 6 January 2017. ...drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects.
  3. "Dictionary Definition".
  4. Pincus DJ, Szefler SJ, Ackerson LM, Martin RJ (June 1995). "Chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 95 (6): 1172–8. doi:10.1016/S0091-6749(95)70073-0. PMID 7797785.
  5. Pincus DJ, Humeston TR, Martin RJ (December 1997). "Further studies on the chronotherapy of asthma with inhaled steroids: the effect of dosage timing on drug efficacy". The Journal of Allergy and Clinical Immunology. 100 (6 Pt 1): 771–4. doi:10.1016/S0091-6749(97)70272-0. PMID 9438485.
  6. Hermida RC, Ayala DE, Portaluppi F (August 2007). "Circadian variation of blood pressure: the basis for the chronotherapy of hypertension". Advanced Drug Delivery Reviews. 59 (9–10): 904–22. doi:10.1016/j.addr.2006.08.003. PMID 17659807.
  7. Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates". The Journal of Clinical Psychiatry. 66 (12): 1535–40. PMID 16401154.
  8. Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression". The Journal of Clinical Psychiatry. 75 (2): 133–40. doi:10.4088/JCP.13m08455. PMID 24345382.
  9. Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates". The Journal of Clinical Psychiatry. 66 (12): 1535–40. PMID 16401154.
  10. Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression". The Journal of Clinical Psychiatry. 75 (2): 133–40. doi:10.4088/JCP.13m08455. PMID 24345382.
  11. Benedetti F, Barbini B, Colombo C, Smeraldi E (December 2007). "Chronotherapeutics in a psychiatric ward". Sleep Medicine Reviews. 11 (6): 509–22. doi:10.1016/j.smrv.2007.06.004. PMID 17689120.
  12. Benedetti F (December 2012). "Antidepressant chronotherapeutics for bipolar depression". Dialogues in Clinical Neuroscience. 14 (4): 401–11. PMC 3553570. PMID 23393416.
  13. Dallaspezia S, Suzuki M, Benedetti F (December 2015). "Chronobiological Therapy for Mood Disorders". Current Psychiatry Reports. 17 (12): 95. doi:10.1007/s11920-015-0633-6. PMID 26478195.
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