Capravirine

Capravirine
Names
	IUPAC name [5-(3,5-Dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl]methyl carbamate
Identifiers
CAS Number	178979-85-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL435128 ;
ChemSpider	1717 ;
PubChem CID	1783;
UNII	VHC779598X ;
CompTox Dashboard (EPA)	DTXSID30170689 ;
	InChI InChI=1S/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27) Key: YQXCVAGCMNFUMQ-UHFFFAOYSA-N ; InChI=1/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27) Key: YQXCVAGCMNFUMQ-UHFFFAOYAP;
	SMILES O=C(OCc2nc(c(Sc1cc(Cl)cc(Cl)c1)n2Cc3ccncc3)C(C)C)N;
Properties
Chemical formula	C20H20Cl2N4O2S
Molar mass	451.37 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer.[1][2] Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.[3][4]

References

PubChem. "Capravirine". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-06-02.
"Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.
"Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.
"A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2019-06-02.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] PubChem. "Capravirine". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-06-02.

[2] "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.

[3] "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.

[4] "A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2019-06-02.