CHIR99021

CHIR99021
Names
	IUPAC name 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile
Identifiers
CAS Number	252917-06-9;
3D model (JSmol)	Interactive image;
ECHA InfoCard	100.236.922
PubChem CID	9956119;
CompTox Dashboard (EPA)	DTXSID90179931 ;
	InChI InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) Key: AQGNHMOJWBZFQQ-UHFFFAOYSA-N;
	SMILES N#CC1=CN=C(NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1;
Properties
Chemical formula	C25H18Cl2N8
Molar mass	501.38 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3.[1] It has proved useful for applications in molecular biology involving the transformation of one cell type to another.[2][3]

References

An WF, Germain AR, Bishop JA, Nag PP, Metkar S, Ketterman J, Walk M, Weiwer M, Liu X, Patnaik D, Zhang YL, Gale J, Zhao W, Kaya T, Barker D, Wagner FF, Holson EB, Dandapani S, Perez J, Munoz B, Palmer M, Pan JQ, Haggarty SJ, Schreiber SL. Discovery of Potent and Highly Selective Inhibitors of GSK3b. Probe Reports from the NIH Molecular Libraries Program Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012. PMID 23658955
Singh VK, Kumar N, Kalsan M, Saini A, Chandra R. Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs). J Stem Cells. 2015;10(1):43-62. PMID 26665937
Takeda Y, Harada Y, Yoshikawa T, Dai P.Chemical compound-based direct reprogramming for future clinical applications. Biosci Rep. 2018 May 8;38(3). pii: BSR20171650. doi:10.1042/BSR20171650 PMID 29739872

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[1] An WF, Germain AR, Bishop JA, Nag PP, Metkar S, Ketterman J, Walk M, Weiwer M, Liu X, Patnaik D, Zhang YL, Gale J, Zhao W, Kaya T, Barker D, Wagner FF, Holson EB, Dandapani S, Perez J, Munoz B, Palmer M, Pan JQ, Haggarty SJ, Schreiber SL. Discovery of Potent and Highly Selective Inhibitors of GSK3b. Probe Reports from the NIH Molecular Libraries Program Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012. PMID 23658955

[2] Singh VK, Kumar N, Kalsan M, Saini A, Chandra R. Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs). J Stem Cells. 2015;10(1):43-62. PMID 26665937

[3] Takeda Y, Harada Y, Yoshikawa T, Dai P.Chemical compound-based direct reprogramming for future clinical applications. Biosci Rep. 2018 May 8;38(3). pii: BSR20171650. doi:10.1042/BSR20171650 PMID 29739872

CHIR99021

See also

References