Blackwater fever

Within a few days of onset there are chills, with rigor, high fever, jaundice, vomiting, rapidly progressive anemia, and dark red or black urine.

The cause of hemolytic crises in this disease is unknown (mainly due to intravascular haemolysis). There is rapid and massive destruction of red blood cells resulting in hemoglobinemia (hemoglobin in the blood, but outside the red blood cells), hemoglobinuria (hemoglobin in urine), intense jaundice, anuria (passing less than 50 milliliters of urine in a day), and finally death in the majority of cases.

The most probable explanation for blackwater fever is an autoimmune reaction apparently caused by the interaction of the malaria parasite and the use of quinine. Blackwater fever is caused by heavy parasitization of red blood cells with Plasmodium falciparum. There has been at least one case, however, attributed to Plasmodium vivax.[1]

Blackwater fever is a serious complication of malaria, but cerebral malaria has a higher mortality rate. Blackwater fever is much less common today than it was before 1950.[2] It may be that quinine plays a role in triggering the condition, and this drug is no longer commonly used for malaria prophylaxis. Quinine remains important for treatment of malaria.

The treatment is antimalarial chemotherapy, intravenous fluid and sometimes supportive care such as intensive care and dialysis.

• Prior to his photography career, Henri Cartier-Bresson[3] contracted blackwater fever while hunting in Western Africa. Expecting to die, he sent instructions to his family on his wishes for a funeral. He made a full recovery.
• Zoologist John Samuel Budgett died from the disease in 1904, after returning from a collecting trip to West Africa, in search of specimens of the fish Polypterus[4].
• Missionary and explorer George Grenfell died after a bad attack of blackwater fever at Basoko on 1 July 1906.
• Jesse Brand, a missionary to the Chat Mountains in India, died of blackwater fever in 1928.
• Actor Don Adams, best known as Maxwell Smart from the popular sitcom Get Smart and as the title character in Inspector Gadget, contracted blackwater fever after being shot in combat at Guadalcanal during World War II. Adams was evacuated from his United States Marine Corps unit to a hospital in New Zealand where he ultimately made a full recovery.
• Humanitarian and MMA fighter Justin Wren contracted malaria, which devolved into blackwater fever, while drilling water-wells for Congo Pygmies in 2013. The affliction nearly claimed Wren's life. He was misdiagnosed four times and required airlift to Uganda, where he narrowly recovered from severe symptoms.[5]
• Aeneas, Jeannie Gunn's husband, is described as having died from Blackwater Fever or Malarial Dysentry at Elsey Station in the Northern Territory in 1903. She later authored the classic account We of the Never Never.
• Bernard Deacon

• Out of Africa, a 1985 film based on the experiences of author Isak Dinesen
• The Queen’s Nose, a 1983 book in which the protagonist’s uncle contracts Blackwater Fever
• The Power of One, a 1992 film based on the book of the same name
• The Bridge on the River Kwai, a 1957 film about prisoners of war in a jungle environment
• At Play in the Fields of the Lord, a 1965 novel by Peter Matthiessen
• West with the Night (1942), African memoir by aviator Beryl Markham
• Burmese Days, a 1934 novel by George Orwell; several associates of Flory are noted to have died of blackwater fever in chapter 5
• Showdown, a 1946 novel by Errol Flynn
• The Heart of the Matter, a 1948 novel by Graham Greene
• Green Hills of Africa, a 1935 novel by Ernest Hemingway
• The Book of Secrets, a 1994 novel by M. G. Vassanji
• Blackwater Fever, a 2008 film by Cyrus Frisch
• The Blackwater Fever, a blues band out of Australia
• An Ice-Cream War, a 1982 novel by William Boyd set during the First World War in German East Africa
• Liberia as I know it, a 1929 novel by medical missionary Clinton Caldwell Boone
• Showa: A History of Japan|Showa 1944–1953 A History of Japan, a 2014 four-part autobiographical graphic novel of the Showa period in Japanese history Shigeru Mizuki