Olmesartan/hydrochlorothiazide

Olmesartan/hydrochlorothiazide, sold under the brand name Benicar HCT among others, is a medication used to treat high blood pressure.[1] It is a combination of olmesartan, an angiotension receptor blocker and hydrochlorothiazide, a diuretic.[1] It may be used if olmesartan is not sufficient to manage blood pressure.[2] It is taken by mouth.[2]

Olmesartan/hydrochlorothiazide
Combination of
HydrochlorothiazideThiazide diuretic
OlmesartanAngiotension receptor blocker
Clinical data
Trade namesBenicar HCT, Benitec H, others
Routes of
administration		By mouth
Legal status
Legal status
  • In general: ℞ (Prescription only)

Common side effects include nausea, dizziness, and upper respiratory tract infections.[3] Serious side effects may include kidney problems, allergic reactions, electrolyte problems and low blood pressure.[3] Use in pregnancy is not recommended.[3] Olmesartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by increasing the loss of sodium by the kidneys.[3]

No generic version is available in the United States as of 2017.[1] A month supply in the United Kingdom costs the NHS about 13 £ as of 2019.[2] In the United States the wholesale cost of this amount is about US$6.[4] In 2016 it was the 258th most prescribed medication in the United States with more than a million prescriptions.[5]

References
  1. Bope, Edward T.; Kellerman, Rick D. (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 9780323443357.
  2. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 177–178. ISBN 9780857113382.
  3. "Olmesartan Medoxomil and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 11 March 2019.
  4. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  5. "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.
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