Batimastat
Batimastat (INN/USAN, codenamed BB-94) is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. It acts as a matrix metalloproteinase inhibitor (MMPI) by mimicking natural MMPI peptides.
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Routes of administration | Injection into pleural space or abdomen |
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ECHA InfoCard | 100.222.897 |
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Formula | C23H31N3O4S2 |
Molar mass | 477.64 g/mol g·mol−1 |
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Batimastat was the first MMPI that went into clinical trials. First results of a Phase I trial appeared in 1994. The drug reached Phase III but was never marketed; mainly because it couldn't be administered orally (as opposed to the newer and chemically similar MMPI marimastat), and injection into the peritoneum caused peritonitis.[1]
References
- Rothenberg, M. L.; Nelson, A. R.; Hande, K. R. (1999). "New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors". Stem Cells. 17 (4): 237–240. doi:10.1002/stem.170237. PMID 10437989.
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