BHF-177

BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2]

BHF-177
Identifiers
CAS Number
IUPHAR/BPS
ChemSpider
Chemical and physical data
FormulaC19H20F3N3
Molar mass347.377 g/mol g·mol−1
3D model (JSmol)
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References
  1. Guery, S; Floersheim, P; Kaupmann, K; Froestl, W (2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors". Bioorganic & Medicinal Chemistry Letters. 17 (22): 6206–11. doi:10.1016/j.bmcl.2007.09.023. PMC 2278029. PMID 17884493.
  2. Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (2008). "Positive Modulation of GABAB Receptors Decreased Nicotine Self-administration and Counteracted Nicotine-induced Enhancement of Brain Reward Function in Rats". J. Pharmacol. Exp. Ther. 326 (1): 306–14. doi:10.1124/jpet.108.139204. PMC 2574924. PMID 18445779.


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