Anti-SSA/Ro autoantibodies

Anti-SSA autoantibodies (Anti-Sjögren’s-syndrome-related antigen A, also called anti-Ro, or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous lupus erythematosus (SCLE), neonatal lupus and primary biliary cirrhosis.[1] Also, they are often present in Sjögren's syndrome.[2] [3]

Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate.

Presence of Anti-SSA/Ro in pregnant women with SLE is associated with an increased risk of neonatal lupus erythematosus which can present with congenital heart block in the fetus.[4]

Ro protein binds to Y RNA.

Epidemiology

Approximately only 0.1 to 0.5 percent of the general population has the antibody. After pregnancy Ana and ro52 results are non valuable due to medicines and treatment taken for pregnancy.

References
  1. Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.
  2. Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706.
  3. V Goëb; et al. (2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome". Clin. Exp. Immunol. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756.
  4. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 160. ISBN 0-7216-2921-0.


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