Aluminium toxicity in people on dialysis

Aluminium toxicity in people on dialysis is a problem for people on haemodialysis. The dialysis process does not efficiently remove excess aluminium from the body, so it may build up over time. Aluminium is a potentially toxic metal, and aluminium poisoning may lead to mainly three disorders: aluminium-induced bone disease, microcytic anemia and neurological dysfunction (encephalopathy). Such conditions are more prominently observed in people with chronic renal failure and especially in people on haemodialysis.

Aluminium toxicity in people on dialysis
Other namesAluminium toxicity

About 5–10 mg of aluminium enters our body daily through different sources like water, food, occupational exposure to aluminium in industries etc.[1] In people with normal renal function, serum aluminium is normally lower than 6 microgram/L.[2] Baseline levels of serum aluminium should be <20 microgram/L.[3] According to AAMI standards aluminum levels in the dialysis fluid should be less than 0.01milligram/L.[4]

References
  1. AB, Edward RA. Fundamentals of clinical chemistry. 5th ed. Saunders: Harcourt India; 652-3
  2. JR, Mohammad AA. Clinical and forensic applications of capillary electrophoresis. Humana press; 388-9
  3. National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in children with chronic kidney disease. Am J Kidney Dis 2005; Oct; 46(4 Suppl 1):S1-121. [557 references]
  4. Your Dialysis Water Treatment System. Published June, 2005. WEBSITE: www.nwrenalnetwork.org Aluminium exposure.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.