ATL-444

ATL-444
Identifiers
	IUPAC name (1S,3R)-1-[2-(6-amino-9-prop-2-ynylpurin-2-yl)ethynyl]-3-methylcyclohexan-1-ol;
PubChem CID	11616539;
ChemSpider	9791288;
Chemical and physical data
Formula	C17H19N5O
Molar mass	309.365 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C#CCN1C=NC2=C1N=C(C#C[C@@]3(CCC[C@H](C3)C)O)N=C2N;
	InChI InChI=1S/C17H19N5O/c1-3-9-22-11-19-14-15(18)20-13(21-16(14)22)6-8-17(23)7-4-5-12(2)10-17/h1,11-12,23H,4-5,7,9-10H2,2H3,(H2,18,20,21)/t12-,17-/m1/s1; Key:VEJLEEFUXFQSHP-SJKOYZFVSA-N;

ATL-444 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A₁ and A_2A. It has been used to study the role of the adenosine receptor system in the reinforcing action of cocaine.[1]

References

Doyle, S. E.; Breslin, F. J.; Rieger, J. M.; Beauglehole, A.; Lynch, W. J. (2012). "Time and sex-dependent effects of an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats". Pharmacology Biochemistry and Behavior. 102 (2): 257–263. doi:10.1016/j.pbb.2012.05.001. PMC 3383440. PMID 22579716.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Doyle, S. E.; Breslin, F. J.; Rieger, J. M.; Beauglehole, A.; Lynch, W. J. (2012). "Time and sex-dependent effects of an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats". Pharmacology Biochemistry and Behavior. 102 (2): 257–263. doi:10.1016/j.pbb.2012.05.001. PMC 3383440. PMID 22579716.

ATL-444

See also

References