AGN-2979

AGN-2979
Clinical data
ATC code	None;
Identifiers
	IUPAC name 3-(3-Dimethylaminopropyl)-3-(3-methoxyphenyl)-4,4-dimethyl-piperidine-2,6-dione;
CAS Number	53873-21-5 103353-87-3 (HCl);
PubChem CID	40914;
ChemSpider	37360 ;
Chemical and physical data
Formula	C19H28N2O3
Molar mass	332.44 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)CC(C1(c2cccc(OC)c2)CCCN(C)C)(C)C;
	InChI InChI=1S/C19H28N2O3/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23) ; Key:UJFNSGBGJMRZKS-UHFFFAOYSA-N ;
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AGN-2979 is a glutarimide tryptophan hydroxylase activation inhibitor.[1][2] It shows antidepressant properties in rodent models of depression.[2]

References

Hasegawa, S; Kanemaru, K; Gittos, M; Diksic, M (15 October 2005). "The Tryptophan Hydroxylase Activation Inhibitor, AGN-2979, Decreases Regional 5-HT Synthesis in the Rat Brain Measured with α-[¹⁴C]methyl-L-tryptophan: an Autoradiographic Study". Brain Research Bulletin. 67 (3): 248–55. doi:10.1016/j.brainresbull.2005.07.009. PMID 16144662.
Gittos, MW; Papp, M (October 2001). "Antidepressant-like Action of AGN 2979, a Tryptophan Hydroxylase Activation Inhibitor, in a Chronic Mild Stress Model of Depression in Rats". European Neuropsychopharmacology. 11 (5): 351–7. doi:10.1016/S0924-977X(01)00103-1. PMID 11597821.

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[Hasegawa-1] Hasegawa, S; Kanemaru, K; Gittos, M; Diksic, M (15 October 2005). "The Tryptophan Hydroxylase Activation Inhibitor, AGN-2979, Decreases Regional 5-HT Synthesis in the Rat Brain Measured with α-[¹⁴C]methyl-L-tryptophan: an Autoradiographic Study". Brain Research Bulletin. 67 (3): 248–55. doi:10.1016/j.brainresbull.2005.07.009. PMID 16144662.

[Gittos-2] Gittos, MW; Papp, M (October 2001). "Antidepressant-like Action of AGN 2979, a Tryptophan Hydroxylase Activation Inhibitor, in a Chronic Mild Stress Model of Depression in Rats". European Neuropsychopharmacology. 11 (5): 351–7. doi:10.1016/S0924-977X(01)00103-1. PMID 11597821.